Endocrine Abstracts

Several differences have been observed in thyroid function parameters between older and younger individuals. Notably, circulating thyroid stimulating hormone (TSH) levels gradually increase with age, a shift shown to extend to extremely high ages. While clinically abnormal thyroid function parameters have been consistently associated with ill health, the mechanisms underlying mild age-related variations in circulating levels of TSH and thyroid hormones and their health consequ...

Thyroid hormones play an important role in all stages of life, including old age. Several differences have been observed in thyroid function parameters with age, including an increase in circulating thyroid stimulating hormone (TSH) levels gradually increase with age. In order to identify determinants of human longevity, the Leiden Longevity Study (LLS) included 421 families with at least two long-lived Caucasian siblings fulfilling the age criteria (men ≥89 years and wo...